~Frontline Plus is a topical medication for the treatment & prevention of ticks and fleas infestations on dogs and puppies from 8 weeks of age. It also controls Flea Allergy Dermatitis and biting lice. Frontline Plus effectively kills fleas by breaks their life cycle and preventing the development of flea eggs and larvae into adult fleas. Frontline Plus contains the active ingredients Fipronil 100g/L and S-methoprene 90g/L. Fipronil works by attacking the nerve cells of fleas, resulting in their becoming disorientated and hyperactive before dying. (S)-methoprene interferes with egg production and hatching of fleas, as well as inhibiting larval development. Consequently, no more pupae are produced, and the flea life cycle is broken.